16.02.2017 Lapatinib resistance in breast cancer cells is accompanied by phosphorylation-mediated reprogramming of glycolysis

We employed explorative mass spectrometry to profile proteome, kinome, and phosphoproteome changes in an established model of lapatinib resistance to systematically investigate initial inhibitor response and subsequent...[more]

11.02.2017 3 Chapters in Methods in Moleulcar Biology: Proteomics

The Chair of Proteomics and Bioanalytics contributed three chapters to a new edition of the Methods in Moleulcar Biology series: Proteomics - Methods and Protocols.[more]

30.01.2017 Building ProteomeTools based on a complete synthetic human proteome

We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research.[more]

17.01.2017 Protein DENEDDYLASE1 counters automodification of neddylating enzymes in Arabidopsis

In eukaryotes, the conjugation of the ubiquitinlike protein NEDD8 onto protein targets is an important post-translational modification. Little is known about the role of other deneddylating enzymes the role of neddylation and...[more]

30.10.2016 Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells

Here we show that epidermal growth factor receptor (EGFR) inhibition by Gefitinib is counteracted by growth factors, notably FGF2, and we assessed the global molecular consequences of this resistance at the proteome and...[more]

21.10.2016 Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs

Here, we used chemical proteomics to survey 235 clinical kinase inhibitors for their kinase selectivity and identified 24 drugs with submicromolar affinities for EPHA2.[more]

20.10.2016 Ethylene glycol improves electrospray ionization efficiency in bottom-up proteomics

Here, we systematically evaluated the concept by screening about 30 compounds with various physico-chemical properties as LC additives.[more]

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