2020

  • Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms.
    Nature chemistry; 2020 Feb DOI: 10.1038/s41557-019-0378-7
    Le P | Kunold E | Macsics R | Rox K | Jennings MC | Ugur I | Reinecke M | Chaves-Moreno D | Hackl MW | Fetzer C | Mandl FAM | Lehmann J | Korotkov VS | Hacker SM | Kuster B | Antes I | Pieper DH | Rohde M | Wuest WM | Medina E | Sieber SA
    Online reference
  • Meltome atlas-thermal proteome stability across the tree of life.
    Nature methods; 2020 Apr 13 DOI: 10.1038/s41592-020-0801-4
    Jarzab A | Kurzawa N | Hopf T | Moerch M | Zecha J | Leijten N | Bian Y | Musiol E | Maschberger M | Stoehr G | Becher I | Daly C | Samaras P | Mergner J | Spanier B | Angelov A | Werner T | Bantscheff M | Wilhelm M | Klingenspor M | Lemeer S | Liebl W | Hahne H | Savitski MM | Kuster B
    Online reference
  • Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC-MS/MS.
    Nature communications; 2020 Jan 9 DOI: 10.1038/s41467-019-13973-x
    Bian Y | Zheng R | Bayer FP | Wong C | Chang YC | Meng C | Zolg DP | Reinecke M | Zecha J | Wiechmann S | Heinzlmeir S | Scherr J | Hemmer B | Baynham M | Gingras AC | Boychenko O | Kuster B
    Online reference
  • Mass-spectrometry-based draft of the Arabidopsis proteome.
    Nature; 2020 Mar DOI: 10.1038/s41586-020-2094-2
    Mergner J | Frejno M | List M | Papacek M | Chen X | Chaudhary A | Samaras P | Richter S | Shikata H | Messerer M | Lang D | Altmann S | Cyprys P | Zolg DP | Mathieson T | Bantscheff M | Hazarika RR | Schmidt T | Dawid C | Dunkel A | Hofmann T | Sprunck S | Falter-Braun P | Johannes F | Mayer KFX | Juergens G | Wilhelm M | Baumbach J | Grill E | Schneitz K | Schwechheimer C | Kuster B
    Online reference
  • 2019

  • Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery
    Target Discovery and Validation: Methods and Strategies for Drug Discovery; 2019 Oct DOI: 10.1002/9783527818242.ch4
    Reinecke M | Heinzlmeir S | Wilhelm M | Medard G | Klaeger S | Kuster B
    Online reference
  • Rebuilding core abscisic acid signaling pathways of Arabidopsis in yeast.
    The EMBO journal; 2019 Sep 2 DOI: 10.15252/embj.2019101859
    Ruschhaupt M | Mergner J | Mucha S | Papacek M | Doch I | Tischer SV | Hemmler D | Chiasson D | Edel KH | Kudla J | Schmitt-Kopplin P | Kuster B | Grill E
    Online reference
  • Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning.
    Nature methods; 2019 Jun DOI: 10.1038/s41592-019-0426-7
    Gessulat S | Schmidt T | Zolg DP | Samaras P | Schnatbaum K | Zerweck J | Knaute T | Rechenberger J | Delanghe B | Huhmer A | Reimer U | Ehrlich HC | Aiche S | Kuster B | Wilhelm M
    Online reference
  • ProteomicsDB: a multi-omics and multi-organism resource for life science research.
    Nucleic acids research; 2019 Oct 30 DOI: 10.1093/nar/gkz974
    Samaras P | Schmidt T | Frejno M | Gessulat S | Reinecke M | Jarzab A | Zecha J | Mergner J | Giansanti P | Ehrlich HC | Aiche S | Rank J | Kienegger H | Krcmar H | Kuster B | Wilhelm M
    Online reference
  • TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach.
    Molecular & cellular proteomics : MCP; 2019 Jul DOI: 10.1074/mcp.TIR119.001385
    Zecha J | Satpathy S | Kanashova T | Avanessian SC | Kane MH | Clauser KR | Mertins P | Carr SA | Kuster B
    Online reference
  • Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors.
    ACS chemical biology; 2019 Apr 19 DOI: 10.1021/acschembio.8b01020
    Reinecke M | Ruprecht B | Poser S | Wiechmann S | Wilhelm M | Heinzlmeir S | Kuster B | Medard G
    Online reference
  • CiRCus: a framework to enable classification of complex high-throughput experiments.
    Journal of proteome research; 2019 Feb DOI: 10.1021/acs.jproteome.8b00724
    Seefried F | Schmidt T | Reinecke M | Heinzlmeir S | Kuster B | Wilhelm M
    Online reference
  • Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues.
    Molecular systems biology; 2019 Feb DOI: 10.15252/msb.20188513
    Eraslan B | Wang D | Gusic M | Prokisch H | Hallstroem BM | Uhlen M | Asplund A | Ponten F | Wieland T | Hopf T | Hahne H | Kuster B | Gagneur J
    Online reference
  • A deep proteome and transcriptome abundance atlas of 29 healthy human tissues.
    Molecular systems biology; 2019 Feb DOI: 10.15252/msb.20188503
    Wang D | Eraslan B | Wieland T | Hallstroem B | Hopf T | Zolg DP | Zecha J | Asplund A | Li LH | Meng C | Frejno M | Schmidt T | Schnatbaum K | Wilhelm M | Ponten F | Uhlen M | Gagneur J | Hahne H | Kuster B
    Online reference
  • Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae.
    Proteomes; 2019 Jan DOI: 10.3390/proteomes7010002
    Rechenberger J | Samaras P | Jarzab A | Behr J | Frejno M | Djukovic A | Sanz J | González-Barberá EM | Salavert M | López-Hontangas JL | Xavier KB | Debrauwer L | Rolain JM | Sanz M | Garcia-Garcera M | Wilhelm M | Ubeda C | Kuster B
    Online reference
  • 2018

  • Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis.
    Cellular and molecular gastroenterology and hepatology; 2018 DOI: 10.1016/j.jcmgh.2018.05.008
    Yoon H | Schaubeck M | Lagkouvardos I | Blesl A | Heinzlmeir S | Hahne H | Clavel T | Panda S | Ludwig C | Kuster B | Manichanh C | Kump P | Haller D | Hoermannsperger G
    Online reference
  • Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients.
    PloS one; 2018 DOI: 10.1371/journal.pone.0193943
    Buhner S | Hahne H | Hartwig K | Li Q | Vignali S | Ostertag D | Meng C | Hoermannsperger G | Braak B | Pehl C | Frieling T | Barbara G | De Giorgio R | Demir IE | Ceyhan GO | Zeller F | Boeckxstaens G | Haller D | Kuster B | Schemann M
    Online reference
  • Adaptive Resistance to EGFR-Targeted Therapy by Calcium Signaling in NSCLC Cells.
    Molecular cancer research : MCR; 2018 Nov DOI: 10.1158/1541-7786.MCR-18-0212
    Mulder C | Prust N | van Doorn S | Reinecke M | Kuster B | van Bergen En Henegouwen P | Lemeer S
    Online reference
  • Expanding the use of spectral libraries in proteomics.
    Journal of proteome research; 2018 Oct 1 DOI: 10.1021/acs.jproteome.8b00485
    Deutsch EW | Perez-Riverol Y | Chalkley RJ | Wilhelm M | Tate S | Sachsenberg T | Walzer M | Kaell L | Delanghe B | Boecker S | Schymanski EL | Wilmes P | Dorfer V | Kuster B | Volders PJ | Jehmlich N | Vissers JPC | Wolan DW | Wang AY | Mendoza L | Shofstahl J | Dowsey AW | Griss J | Salek RM | Neumann S | Binz PA | Lam H | Vizcaíno JA | Bandeira N | Roest H
    Online reference
  • Dynamic Proteome Alteration and Functional Modulation of Human Saliva Induced by Dietary Chemosensory Stimuli.
    Journal of agricultural and food chemistry; 2018 Jun 6 DOI: 10.1021/acs.jafc.8b02092
    Bader M | Dunkel A | Wenning M | Kohler B | Medard G | Del Castillo E | Gholami A | Kuster B | Scherer S | Hofmann T
    Online reference
  • NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
    ChemMedChem; 2018 Aug 20 DOI: 10.1002/cmdc.201800398
    Troester A | Heinzlmeir S | Berger BT | Gande SL | Saxena K | Sreeramulu S | Linhard V | Nasiri AH | Bolte M | Mueller S | Kuster B | Medard G | Kudlinzki D | Schwalbe H
    Online reference
  • Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics.
    Molecular & cellular proteomics : MCP; 2018 May DOI: 10.1074/mcp.RA118.000583
    Zecha J | Meng C | Zolg DP | Samaras P | Wilhelm M | Kuster B
    Online reference
  • ProteomeTools: Systematic characterization of 21 post-translational protein modifications by LC-MS/MS using synthetic peptides.
    Molecular & cellular proteomics : MCP; 2018 May 29 DOI: 10.1074/mcp.TIR118.000783
    Zolg DP | Wilhelm M | Schmidt T | Medard G | Zerweck J | Knaute T | Wenschuh H | Reimer U | Schnatbaum K | Kuster B
    Online reference
  • Mining the human tissue proteome for protein citrullination.
    Molecular & cellular proteomics : MCP; 2018 Apr 2 DOI: 10.1074/mcp.RA118.000696
    Lee CY | Wang D | Wilhelm M | Zolg DP | Schmidt T | Schnatbaum K | Reimer U | Ponten F | Uhlen M | Hahne H | Kuster B
    Online reference
  • 2017

  • The target landscape of clinical kinase drugs.
    Science; 2017 Dec 1 DOI: 10.1126/science.aan4368
    Klaeger S | Heinzlmeir S | Wilhelm M | Polzer H | Vick B | Koenig PA | Reinecke M | Ruprecht B | Petzoldt S | Meng C | Zecha J | Reiter K | Qiao H | Helm D | Koch H | Schoof M | Canevari G | Casale E | Depaolini SR | Feuchtinger A | Wu Z | Schmidt T | Rueckert L | Becker W | Huenges J | Garz AK | Gohlke BO | Zolg DP | Kayser G | Vooder T | Preissner R | Hahne H | Tõnisson N | Kramer K | Goetze K | Bassermann F | Schlegl J | Ehrlich HC | Aiche S | Walch A | Greif PA | Schneider S | Felder ER | Ruland J | Medard G | Jeremias I | Spiekermann K | Kuster B
    Online reference
  • The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.
    Cell reports; 2017 Dec 26 DOI: 10.1016/j.celrep.2017.12.018
    Schneider KS | Gross CJ | Dreier RF | Saller BS | Mishra R | Gorka O | Heilig R | Meunier E | Dick MS | Ćiković T | Sodenkamp J | Medard G | Naumann R | Ruland J | Kuster B | Broz P | Gross O
    Online reference
  • N-Heterocyclic carbenes on close-packed coinage metal surfaces: bis-carbene metal adatom bonding scheme of monolayer films on Au, Ag and Cu
    Chem. Sci.; 2017 Dec DOI: 10.1039/C7SC03777E
    Jiang L | Zhang B | Medard G | Seitsonen A P | Haag F | Allegretti F | Reichert J | Kuster B | Barth J V | Papageorgiou A C
    Online reference
  • Target and identify: Triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy
    Chem Commun; 2017 Oct DOI: 10.1039/C7CC07001B
    Lohse J | Schindl A | Danda N | Williams C P | Kramer K | Kuster B | Witte MD | Medard G
    Online reference
  • Salivary Proteome Patterns Affecting Human Salt Taste Sensitivity
    J. Agric. Food Chem.; 2017 Oct DOI: 10.1021/acs.jafc.7b03862
    Stolle T | Grondinger F | Dunkel A | Meng C | Medard G | Kuster B | Hofmann T
    Online reference
  • Pharmacoproteomic characterisation of human colon and rectal cancer
    Mol Syst Biol; 2017 Nov DOI: 10.15252/msb.20177701
    Frejno M | Zenezini Chiozzi R | Wilhelm M | Koch H | Zheng R | Klaeger S | Ruprecht B | Meng C | Kramer K | Jarzab A | Heinzlmeir S | Johnstone E | Domingo E | Kerr D | Jesinghaus M | Slotta-Huspenina J | Weichert W | Knapp S | Feller SM | Kuster B
    Online reference
  • ProteomicsDB
    Nucleic Acids Research; 2017 Nov DOI: 10.1093/nar/gkx1029
    Schmidt T | Samaras P | Frejno M | Gessulat S | Kuster B | Wilhelm M | Barnert M | Kienegger H | Krcmar H | Schlegl J | Ehrlich HC | Aiche S
    Online reference
  • Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening
    Mol Cell; 2017 Aug DOI: 10.1016/j.molcel.2017.07.019
    Arduino DM | Wettmarshausen J | Vais H | Navas-Navarro P | Cheng Y | Leimpek A | Ma Z | Delrio-Lorenzo A | Giordano A | Garcia-Perez C | Medard G | Kuster B | Garcia-Sancho J | Mokranjac D | Foskett JK | Alonso MT | Perocchi F
    Online reference
  • Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors
    ChemMedChem; 2017 Jun DOI: 10.1002/cmdc.201700217
    Heinzlmeir S | Lohse J | Treiber T | Kudlinzki D | Linhard V | Gande SL | Sreeramulu S | Saxena K | Liu X | Wilhelm M | Schwalbe H | Kuster B | Medard G
    Online reference
  • PROCAL: A set of 40 peptide standards for retention time indexing, column performance monitoring and collision energy calibration
    PROTEOMICS; 2017 Sept DOI: 10.1002/pmic.201700263
    Zolg DP | Wilhelm M | Yu P | Knaute T | Zerweck J | Wenschuh H | Reimer U | Schnatbaum K | Kuster B
    Online reference
  • Trimodal mixed mode chromatography enables efficient offline 2D peptide fractionation for proteome analysis
    Analytical Chemistry; 2017 Aug DOI: 10.1021/acs.analchem.7b01356
    Yu P | Petzoldt S | Wilhelm M | Zolg DP | Zheng R | Sun X | Liu X | Schneider G | Huhmer A | Kuster B
    Online reference
  • Bacterial cellulose shifts transcriptome and proteome of cultured endothelial cells towards native differentiation
    Molecukar & cellular proteomics; 2017 Jun DOI: 10.1074/mcp.RA117.000001
    Feil G | Horres R | Schulte J | Mack AF | Petzoldt S | Arnold C | Meng C | Jost L | Boxleitner J | Kiessling-Wolf N | Serbest E | Helm D | Kuster B | Hartmann I | Korff T | Hahne H
    Online reference
  • Hydrophilic Strong Anion Exchange (hSAX) Chromatography Enables Deep Fractionation of Tissue Proteomes
    Methods Mol Biol; 2017 DOI: 10.1007/978-1-4939-6747-6_7
    Ruprecht B | Wang D | Chiozzi RZ | Li LH | Hahne H | Kuster B
    Online reference
  • Label-free quantitative proteome analysis of the surface-bound salivary pellicle
    Colloids Surf., B; 2017 Apr DOI: 10.1016/j.colsurfb.2017.01.005
    Delius J | Trautmann S | Medard G | Kuster B | Hannig M | Hofmann T
  • Targeted Diazotransfer Reagents Enable Selective Modi?cation of Proteins with Azides (in press)
    Bioconjugate Chem; 2017 DOI: 10.1021/acs.bioconjchem.7b00110
    Lohse J | Swier LJYM | Oudshoorn RC | Medard G | Kuster B | Slotboom DJ | Witte MD
    Online reference
  • Effect of Astringent Stimuli on Salivary Protein Interactions Elucidated by Complementary Proteomics Approaches
    J Agric Food Chem; 2017 DOI: 10.1021/acs.jafc.7b00436
    Delius J | Medard G | Kuster B | Hofmann T
    Online reference
  • Ethylene glycol improves electrospray ionization efficiency in bottom-up proteomics
    Anal Bioanal Chem; 2017 Feb DOI: 10.1007/s00216-016-0023-x
    Yu P | Hahne H | Wilhelm M | Kuster B
    Online reference
  • Optimized Enrichment of Phosphoproteomes by Fe-IMAC Column Chromatography
    Methods Mol Biol; 2017 DOI: 10.1007/978-1-4939-6747-6_5
    Ruprecht B | Koch H | Domasinska P | Frejno M | Kuster B | Lemeer S
    Online reference
  • High pH Reversed-Phase Micro-Columns for Simple, Sensitive, and Efficient Fractionation of Proteome and (TMT labeled) Phosphoproteome Digests
    Methods Mol Biol; 2017 DOI: 10.1007/978-1-4939-6747-6_8
    Ruprecht B | Zecha J | Zolg DP | Kuster B
    Online reference
  • Building ProteomeTools based on a complete synthetic human proteome
    Nature Methods; 2017 Mar DOI: 10.1038/nmeth.4153
    Zolg DP | Wilhelm M | Schnatbaum K | Zerweck J | Knaute T | Delanghe B | Baily DJ | Gessulat S | Ehrlich HC | Weiniger M | Yu P | Schlegl J | Kramer K | Schmidt T | Kusebauch U | Deutsch EW | Aebersold R | Moritz RL | Wenschuh H | Moering T | Aiche S | Huhmer A | Reimer U | Kuster B
    Online reference
  • DENEDDYLASE1 Protein Counters Automodification of Neddylating Enzymes to Maintain NEDD8 Protein Homeostasis in Arabidopsis
    J Biol Chem; 2017 Mar DOI: 10.1074/jbc.M116.767103
    Mergner J | Kuster B | Schwechheimer C
    Online reference
  • Lapatinib resistance in breast cancer cells is accompanied by phosphorylation-mediated reprogramming of glycolysis.
    Cancer Res; 2017 Feb DOI: 10.1158/0008-5472.CAN-16-2976
    Ruprecht B | Zaal EA | Zecha J | Wu W | Berkers CR | Kuster B | Lemeer S
    Online reference
  • 2016

  • Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC)
    BMC Genomics; 2016 Feb DOI: 10.1186/s12864-016-2456-1
    Neuhaus K | Landstorfer R | Fellner L | Simon S | Schafferhans A | Goldberg T | Marx H | Ozoline ON | Rost B | Kuster B | Keim DA | Scherer S | Fredebohm J
    Online reference
  • Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity
    Nat Med; 2016 Jul DOI: 10.1038/nm.4128
    Eichner R | Heider M | Fernandez-Saiz V | van Bebber F | Garz AK | Lemeer S | Rudelius M | Targosz BS | Jacobs L | Knorn AM | Slawaska J | Platzbecker U | Germing U | Langer C | Knop S | Einsele H | Peschel C | Haass C | Keller U | Schmid B | Gotze KS | Kuster B | Bassermann F
    Online reference
  • Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice
    Physiol Rep; 2016 Oct DOI: 10.14814/phy2.12988
    Lohr K | Pachl F | Moghaddas Gholami A | Geillinger KE | Daniel H | Kuster B | Klingenspor M
    Online reference
  • K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria
    Immunity ; 2016 Oct DOI: 10.1016/j.immuni.2016.08.010
    Groß CJ | Mishra R | Schneider KS | Medard G | Wettmarshausen J | Dittlein DC | Shi H | Gorka O | Koenig PA | Fromm S | MagnaniG | Ćiković T | Hartjes L | Smollich J | Robertson AA | Cooper MA | Schmidt-Supprian M | Schuster M | Schroder K | Broz P | Traidl-Hoffmann C | Beutler B | Kuster B | Ruland J | Schneider S
    Online reference
  • MALDI-TOF and nESI Orbitrap MS/MS identify orthogonal parts of the phosphoproteome
    Proteomics; 2016 May DOI: 10.1002/pmic.201500523
    Ruprecht B | Roesli C | Lemeer S | Kuster B
    Online reference
  • Cell cycle-regulated PLEIADE/AtMAP65-3 links membrane and microtubule dynamics during plant cytokinesis
    Plant J.; 2016 Nov DOI: 10.1111/tpj.13275
    Steiner A | Rybak K | Altmann M | McFarlane HE | Klaeger S | Nguyen N | Facher E | Ivakov A | Wanner G | Kuster B | Persson S | Braun P | Hauser MT | Assaad FF | Boettcher M
    Online reference
  • A bead-based western for high-throughput cellular signal transduction analyses
    Nature Communications; 2016 Sep DOI: 10.1038/ncomms12852
    Treindl F | Ruprecht B | Beiter Y | Schultz S | Döttinger A | Staebler A | Joos TO | Kling S | Poetz O | Fehm T | Neubauer H | Kuster B | Templin MF
    Online reference
  • Expression and Purification of EPHA2 Tyrosine Kinase Domain for Crystallographic and NMR Studies.
    Chembiochem; 2016 Dec DOI: 10.1002/cbic.201600483
    Gande SL | Saxena K | Sreeramulu S | Linhard V | Kudlinzki D | Heinzlmeir S | Reichert AJ | Skerra A | Kuster B | Schwalbe H
    Online reference
  • ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer
    Oncotarget; 2016 Dec DOI: 10.18632/oncotarget.13086
    Strietz J | Stepputtis SS | Preca BT | Vannier C | Kim MM | Castro DJ | Au Q | Boerries M | Busch H | Aza-Blanc P | Heynen-Genel S | Bronsert P | Kuster B | Stickeler E | Brabletz T | Oshima RG | Maurer J | Boettcher M
    Online reference
  • Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors
    ACS Chemical Biology; 2016 Feb DOI: 10.1021/acschembio.5b01063
    Klaeger S | Gohlke B | Perrin J | Gupta V | Heinzlmeir S | Helm D | Qiao H | Bergamini G | Handa H | Savitski MM | Bantscheff M | Medard G | Preissner R | Kuster B
    Online reference
  • Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
    ACS Chem Biol; 2016 Oct
    Heinzlmeir S | Kudlinzki D | Sreeramulu S | Klaeger S | Gande S | Linhard V | Wilhelm M | Qiao H | Helm D | Ruprecht B | Saxena K | Medard G | Schwalbe H | Kuster B
    Online reference
  • Phosphoproteome profiling reveals molecular mechanisms of growth factor mediated kinase inhibitor resistance in EGFR overexpressing cells.
    J Proteome Res; 2016 Oct 30 DOI: 10.1021/acs.jproteome.6b00621
    Koch H | Wilhelm M | Ruprecht B | Beck S | Frejno M | Klaeger S | Kuster B
    Online reference
  • Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).
    Future Med Chem; 2016 Sept DOI: 10.4155/fmc-2016-0132
    Ostrovskyi D | Rumpf T | Eib J | Lumbroso A | Slynko I | Klaeger S | Heinzlmeir S | Forster M | Gehringer M | Pfaffenrot E | Bauer SM | Schmidtkunz K | Wenzler S | Metzger E | Kuster B | Laufer S | Schüle R | Sippl W | Breit B | Jung M
    Online reference
  • Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing.
    ChemMedChem; 2016 Jul 29 DOI: 10.1002/cmdc.201600284
    Slynko I | Schmidtkunz K | Rumpf T | Klaeger S | Heinzlmeir S | Najar A | Metzger E | Kuster B | Schüle R | Jung M | Sippl W
    Online reference
  • Towards Understanding Male Infertility After Spinal Cord Injury Using Quantitative Proteomics
    Mol Cell Proteomics; 2016 Apr DOI: 10.1074/mcp.M115.052175
    da Silva BF | Meng C | Helm D | Pachl F | Schiller J | ibrahim E | Lynne CM | Brackett NL | Bertolla RP | Kuster B
    Online reference
  • Dimension reduction techniques for the integrative analysis of multi-omics data
    Brief Bioinform.; 2016 Jul DOI: 10.1093/bib/bbv108
    Meng C | Zeleznik OA | Thallinger GG | Kuster B | Gholami AM | Culhane AC
    Online reference
  • moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets
    J. Proteome Res.; 2016 Mar DOI: 10.1021/acs.jproteome.5b00824
    Meng C | Helm D | Frejno M | Kuster B
    Online reference
  • 2015

  • Evaluation of Kinase Activity Profiling Using Chemical Proteomics.
    ACS Chem Biol.; 5 October 2015 DOI: 10.1021/acschembio.5b00616
    Ruprecht B | Zecha J | Heinzlmeir S | Medard G | Lemeer S | Kuster B
    Online reference
  • Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells.
    ACS Chem Biol.; 2015 Aug 27. [Epub ahead of print] DOI: 10.1021/acschembio.5b00565
    Scharow A | Raab M | Saxena K | Sreeramulu S | Kudlinzki D | Gande S | Dötsch C | Kurunci-Csacsko E | Klaeger S | Kuster B | Schwalbe H | Strebhardt K | Berg T
    Online reference
  • Semi-supervised Learning Predicts Approximately One Third of the Alternative Splicing Isoforms as Functional Proteins.
    Cell Rep.; 2015 Jul 1. pii: S2211-1247(15)00643-9. DOI: 10.1016/j.celrep.2015.06.031
    Hao Y | Colak R | Teyra J | Corbi-Verge C | Ignatchenko A | Hahne H | Wilhelm M | Kuster B | Braun P | Kaida D | Kislinger T | Kim PM
    Online reference
  • A scalable approach for protein false discovery rate estimation in large proteomic data sets.
    Mol Cell Proteomics.; 2015 May 17. DOI: pii: mcp.M114.046995
    Wilhelm M | Savitski MM | Hahne H | Kuster B | Bantscheff M
    Online reference
  • Chemical proteomics uncovers EPHA2 as a mechanism of acquired resistance to small molecule EGFR kinase inhibition.
    J Proteome Res.; 2015 Jun 5;14(6):2617-25. DOI: 10.1021/acs.jproteome.5b00161
    Koch H | Del Castillo Busto ME | Kramer K | Medard G | Kuster B
    Online reference
  • DENEDDYLASE1 Deconjugates NEDD8 from Non-Cullin Protein Substrates in Arabidopsis thaliana.
    Plant Cell.; 2015 Mar;27(3):741-53. DOI: 10.1105/tpc.114.135996
    Mergner J | Heinzlmeir S | Kuster B | Schwechheimer C
    Online reference
  • Novel Flp pilus biogenesis-dependent natural transformation.
    Front Microbiol.; 2015 Feb 10;6:84 DOI: 10.3389/fmicb.2015.00084
    Angelov A | Bergen P | Nadler F | Hornburg P | Lichev A | Pachl F | Kuster B | Liebl W
    Online reference
  • Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.
    Mol Oncol.; 2015 Jan;9(1):140-54. DOI: 10.1016/j.molonc.2014.07.020
    Raab M | Krämer A | Hehlgans S | Sanhaji M | Kurunci-Csacsko E | Dötsch C | Bug G | Ottmann O | Becker S | Pachl F | Kuster B | Strebhardt K
    Online reference
  • Optimized chemical proteomics assay for kinase inhibitor profiling.
    J Proteome Res.; 2015 Feb 8. DOI: 10.1021/pr5012608
    Medard G | Pachl F | Ruprecht B | Klaeger S | Heinzlmeir S | Helm D | Qiao H | Ku X | Wilhelm M | Kuehne T | Wu Z | Dittmann A | Hopf C | Kramer K | Kuster B
    Online reference
  • Comprehensive and Reproducible Phosphopeptide Enrichment Using Iron Immobilized Metal Ion Affinity Chromatography (Fe-IMAC) Columns.
    Mol Cell Proteomics.; 2015 Jan;14(1):205-15. DOI: 10.1074/mcp.M114.043109
    Ruprecht B | Koch H | Medard G | Mundt M | Kuster B | Lemeer S
    Online reference
  • Quantitative Proteome Profiling of human Myoma and Myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention.
    Proteomics.; 2015 Jan;15(2-3):356-64. DOI: 10.1002/pmic.201400213
    Lemeer S | Gholami AM | Wu Z | Kuster B
    Online reference
  • 2014

  • Probing SH2-domains using Inhibitor Affinity Purification (IAP).
    Proteome Sci; 2014 Jul DOI: 10.1186/1477-5956-12-41
    Hoefener M | Heinzlmeir S | Kuster B | Sewald N
    Online reference
  • Plant cytokinesis is orchestrated by the sequential action of the TRAPPII and exocyst tethering complexes
    Dev Cell; 2014 Jun 9;29(5):607-20 DOI: 10.1016/j.devcel.2014.04.029
    Rybak K | Steiner A | Synek L | Klaeger S | Kulich I | Facher E | Wanner G | Kuster B | Zarsky V | Persson S | Assaad FF
    Online reference
  • Tracking cancer drugs in living cells by thermal profiling of the proteome
    Science; 2014 Oct 3;346(6205):1255784. DOI: 10.1126/science.1255784
    Savitski MM | Reinhard FB | Franken H | Werner T | Savitski MF | Eberhard D | Martinez Molina D | Jafari R | Dovega RB | Klaeger S | Kuster B | Nordlund P | Bantscheff M | Drewes G
    Online reference
  • Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics.
    Mol Cell Proteomics.; 2014 Dec;13(12):3709-15. DOI: 10.1074/mcp.M114.041038
    Helm D | Vissers JP | Hughes CJ | Hahne H | Ruprecht B | Pachl F | Grzyb A | Richardson K | Wildgoose J | Maier SK | Marx H | Wilhelm M | Becher I | Lemeer S | Bantscheff M | Langridge JI | Kuster B
    Online reference
  • PAS-cal: a Generic Recombinant Peptide Calibration Standard for Mass Spectrometry.
    J Am Soc Mass Spectrom.; 2014 Aug;25(8):1489-97 DOI: 1007/s13361-014-0902-3
    Breibeck J | Serafin A | Reichert A | Maier S | Kuster B | Skerra A
    Online reference
  • A multivariate approach to the integration of multi-omics datasets.
    BMC Bioinformatics.; 2014 May 29;15(1):162 DOI: 10.1186/1471-2105-15-162
    Meng C | Kuster B | Culhane AC | Moghaddas Gholami A
    Online reference
  • Mass-spectrometry-based draft of the human proteome
    Nature.; 2014 May 29;509(7502):582-7. DOI: 10.1038/nature13319.
    Wilhelm M | Schlegl J | Hahne H | Moghaddas Gholami A | Lieberenz M | Savitski MM | Ziegler E | Butzmann L | Gessulat S | Marx H | Mathieson T | Lemeer S | Schnatbaum K | Reimer U | Wenschuh H | Mollenhauer M | Slotta-Huspenina J | Boese JH | Bantscheff M | Gerstmair A | Faerber F | Kuster B
    Online reference
  • New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics.
    J Proteome Res.; 2014 May 2;13(5):2445-52 DOI: 10.1021/pr40124t
    Ku X | Heinzlmeir S | Helm D | Medard G | Kuster B
    Online reference
  • A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors.
    J Proteomics; 2014 Jan;96:44-55. DOI: 10.1016/j.jprot.2013.10.031
    Ku X | Heinzlmeir S | Liu X | Medard G | Kuster B
    Online reference
  • High-fat diet alters gut microbiota physiology in mice.
    ISME J.; 2014 Feb;8(2):295-308 DOI: 10.1038/ismej.2013.155
    Daniel H | Gholami AM | Berry D | Desmarchelier C | Hahne H | Loh G | Mondot S | Lepage P | Rothballer M | Walker A | Böhm C | Wenning M | Wagner M | Blaut M | Schmitt-Kopplin P | Kuster B | Haller D | Clavel T
    Online reference
  • 2013

  • ML3 is a NEDD8- and ubiquitin-modified protein.
    Plant Physiol; 2013 Sep DOI: 10.1104/pp.113.221341
    Hakenjos JP | Bejai S | Ranftl Q | Behringer C | Vlot AC | Absmanner B | Hammes U | Heinzlmeir S | Kuster B | Schwechheimer C
    Online reference
  • DMSO enhances electrospray response, boosting sensitivity of proteomic experiments.
    Nat Methods.; 2013 Oct 10(10):989-91 DOI: 10.1038/nmeth.2610
    Hahne H | Pachl F | Ruprecht B | Maier SK | Klaeger S | Helm D | Medard G | Wilm M | Lemeer S | Kuster B
    Online reference
  • Global Proteome Analysis of the NCI-60 Cell Line Panel.
    Cell Rep.; 2013 Aug 15;4(3):609-20. DOI: 10.1016/j.celrep.2013.07.018
    Gholami AM | Hahne H | Wu Z | Auer FJ | Meng C | Wilhelm M | Kuster B
    Online reference
  • Measuring and Managing Ratio Compression for Accurate iTRAQ/TMT Quantification.
    J Proteome Res.; 2013 Jul 2. [Epub ahead of print]
    Savitski MM | Mathieson T | Zinn N | Sweetman G | Doce C | Becher I | Pachl F | Kuster B | Bantscheff M
    Online reference
  • Characterization of a Chemical Affinity Probe Targeting Akt Kinases.
    J Proteome Res.; 2013 Aug 2;12(8):3792-800 DOI: 10.1021/pr400455j
    Pachl F | Plattner P | Ruprecht B | Medard G | Sewald N | Kuster B
    Online reference
  • Characterization of a high field Orbitrap mass spectrometer for proteome analysis.
    Proteomics.; 2013 Jul 8. [Epub ahead of print] DOI: 10.1002/pmic.201300076
    Pachl F | Ruprecht B | Lemeer S | Kuster B
    Online reference
  • Co-immunoprecipitation-based identification of putative BAX INHIBITOR-1-interacting proteins involved in cell death regulation and plant-powdery mildew interactions.
    Mol Plant Pathol.; 2013 Jun 19. [Epub ahead of print] DOI: 10.1111/mpp.12050
    Weis C | Pfeilmeier S | Glawischnig E | Isono E | Pachl F | Hahne H | Kuster B | Eichmann R | Hückelhoven R
    Online reference
  • Comprehensive identification of proteins from MALDI imaging.
    Mol Cell Proteomics.; 2013 Jun 19. [Epub ahead of print]
    Maier SK | Hahne H | Moghaddas Gholami A | Balluff B | Meding S | Schöne C | Walch A | Kuster B
    Online reference
  • A large synthetic peptide and phosphopeptide reference library for mass spectrometry-based proteomics.
    Nat Biotechnol.; 2013 May 19. [Epub ahead of print] DOI: 10.1038/nbt.2585
    Marx H | Lemeer S | Schliep JE | Matheron L | Mohammed S | Cox J | Mann M | Heck AJ | Kuster B
    Online reference
  • MScDB: A Mass Spectrometry Centric Protein Sequence Database for Proteomics.
    J Proteome Res.; 2013 Apr 30. [Epub ahead of print]
    Marx H | Lemeer S | Klaeger S | Rattei T | Kuster B
    Online reference
  • Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria.
    J Pathol.; 2013 Apr 16. [Epub ahead of print] DOI: 10.1002/path.4199
    Aichler M | Elsner M | Ludyga N | Feuchtinger A | Zangen V | Maier SK | Balluff B | Schöne C | Hierber L | Braselmann H | Meding S | Rauser S | Zischka H | Aubele M | Schmitt M | Feith M | Hauck SM | Ueffing M | Langer R | Kuster B | Zitzelsberger H | Höfler H | Walch A
    Online reference
  • Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity.
    J Proteome Res.; 2013 Mar 15. [Epub ahead of print]
    Lemeer S | Ruprecht B | Zörgiebel C | Kohl K | Kuster B
    Online reference
  • A public-private partnership to unlock the untargeted kinome
    Nat Chem Biol.; 2013 Jan;9(1):3-6. DOI: 10.1038/nchembio.1113
    Knapp S | Arruda P | Blagg J | Burley S | Drewry DH | Edwards A | Fabbro D | Gillespie P | Gray NS | Kuster B | Lackey KE | Mazzafera P | Tomkinson NC | Willson TM | Workman P | Zuercher WJ
    Online reference
  • Proteome wide purification and identification of O-GlcNAc modified proteins using Click chemistry and mass spectrometry.
    J Proteome Res.; 2013 Jan 9. [Epub ahead of print]
    Hahne H | Sobotzki N | Nyberg T | Helm D | Borodkin VS | van Aalten DM | Agnew B | Kuster B
    Online reference
  • 2012

  • Quantitative mass spectrometry in proteomics.
    Anal Bioanal Chem.; 2012 Sep;404(4):937-8. DOI: 10.1007/s00216-012-6261-7
    Bantscheff M | Kuster B
    Online reference
  • Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present.
    Anal Bioanal Chem.; 2012 Sep;404(4):939-65. Epub 2012 Jul 8. DOI: 10.1007/s00216-012-6203-4
    Bantscheff M | Lemeer S | Savitski MM | Kuster B
    Online reference
  • MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma.
    J Proteomics.; 2012 Aug 3;75(15):4693-704. Epub 2012 Feb 17. DOI: 10.1016/j.jprot.2012.02.012
    Elsner M | Rauser S | Maier S | Schöne C | Balluff B | Meding S | Jung G | Nipp M | Sarioglu H | Maccarrone G | Aichler M | Feuchtinger A | Langer R | Jütting U | Feith M | Kuster B | Ueffing M | Zitzelsberger H | Höfler H | Walch A
    Online reference
  • SCF(Fbxo9) and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
    Nat Cell Biol.; 2012 Dec 23. [Epub ahead of print] DOI: 10.1038/ncb2651
    Fernández-Sáiz V | Targosz BS | Lemeer S | Eichner R | Langer C | Bullinger L | Reiter C | Slotta-Huspenina J | Schroeder S | Knorn AM | Kurutz J | Peschel C | Pagano M | Kuster B | Bassermann F
    Online reference
  • A Simple and Effective Cleavable Linker for Chemical Proteomics Applications.
    Mol Cell Proteomics.; 2012 Oct 1. [Epub ahead of print]
    Yang Y | Hahne H | Kuster B | Verhelst SH
    Online reference
  • Discovery of O-GlcNAc-6-phosphate-modified proteins by re-analyzing large-scale phosphoproteomics data.
    Mol Cell Proteomics.; 2012 Jul 23. [Epub ahead of print]
    Hahne H | Kuster B
    Online reference
  • MALDI Imaging Mass Spectrometry for In Situ Proteomic Analysis of Preneoplastic Lesions in Pancreatic Cancer.
    PLoS One.; 2012;7(6):e39424. Epub 2012 Jun 26.
    Grüner BM | Hahne H | Mazur PK | Trajkovic-Arsic M | Maier S | Esposito I | Kalideris E | Michalski CW | Kleeff J | Rauser S | Schmid RM | Kuster B | Walch A | Siveke JT
    Online reference
  • Software Tools for MS-Based Quantitative Proteomics: A Brief Overview.
    Methods Mol Biol.; 2012;893:489-99.
    Lemeer S | Hahne H | Pachl F | Kuster B
    Online reference
  • Discovery of O-GlcNAc-modified proteins in published large-scale proteome data.
    Mol Cell Proteomics.; 2012 Jun 1. [Epub ahead of print]
    Hahne H | Gholami AM | Kuster B
    Online reference
  • Ultra-high intra-spectrum mass accuracy enables unambiguous identification of fragment reporter ions in isobaric multiplexed quantitative proteomics.
    Proteomics.; 2012 May;12(9):1328-32. DOI: 10.1002/pmic.201100622
    Pachl F | Fellenberg K | Wagner C | Kuster B
    Online reference
  • Lactocepin secreted by lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines.
    Cell Host Microbe.; 2012 Apr 19;11(4):387-96.
    von Schillde MA | Hörmannsperger G | Weiher M | Alpert CA | Hahne H | Bäuerl C | van Huynegem K | Steidler L | Hrncir T | Pérez-Martínez G | Kuster B | Haller D
    Online reference
  • Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans.
    Anal Chem.; 2012 Mar 28. [Epub ahead of print]
    Hahne H | Neubert P | Kuhn K | Etienne C | Bomgarden RD | Rogers JC | Kuster B
    Online reference
  • Phosphorylation site localization in peptides by MALDI MS/MS and the Mascot Delta Score.
    Anal Bioanal Chem.; 2012 Jan;402(1):249-60. Epub 2011 Oct 25.
    Lemeer S | Kunold E | Klaeger S | Raab M | Towers MW | Claudes E | Arrey TN | Strupat K | Urlaub H | Kuster B
    Online reference
  • Systematic identification of the HSP90 regulated proteome.
    Mol Cell Proteomics.; 2012 Feb 14. [Epub ahead of print]
    Wu Z | Moghaddas Gholami A | Kuster B
    Online reference
  • Affinity purification of proteins binding to kinase inhibitors immobilized on self-assembling monolayers.
    Methods Mol Biol.; 2012;795:149-60.
    Bantscheff M | Hobson S | Kuster B
    Online reference
  • 2011

  • Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1.
    J Proteomics.; 2011 Oct 26. [Epub ahead of print]
    Lemeer S | Bluwstein A | Wu Z | Leberfinger J | Müller K | Kramer K | Kuster B
    Online reference
  • Phosphorylation site localization in peptides by MALDI MS/MS and the Mascot Delta Score.
    Anal Bioanal Chem.; 2012 Jan;402(1):249-60. Epub 2011 Oct 25.
    Lemeer S | Kunold E | Klaeger S | Raab M | Towers MW | Claudes E | Arrey TN | Strupat K | Urlaub H | Kuster B
    Online reference
  • Confident phosphorylation site localization using the Mascot Delta Score.
    Mol Cell Proteomics.; 2011 Feb;10(2):M110.003830. Epub 2010 Nov 6.
    Savitski MM | Lemeer S | Boesche M | Lang M | Mathieson T | Bantscheff M | Kuster B
    Online reference
  • Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.
    Mol Cell Proteomics.; 2011 Sep 28. [Epub ahead of print]
    Wu Z | Doondeea JB | Moghaddas Gholami A | Janning MC | Lemeer S | Kramer K | Eccles SA | Gollin SM | Grenman R | Walch A | Feller SM | Kuster B
    Online reference
  • Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation.
    Gastroenterology.; 2011 May 26. [Epub ahead of print]
    Steck N | Hoffmann M | Sava IG | Kim SC | Hahne H | Tonkonogy SL | Mair K | Krueger D | Pruteanu M | Shanahan F | Vogelmann R | Schemann M | Kuster B | Sartor RB | Haller D
    Online reference
  • A Novel Two-Stage Tandem Mass Spectrometry Approach and Scoring Scheme for the Identification of O-GlcNAc Modified Peptides.
    J Am Soc Mass Spectrom.; 2011 May;22(5):931-42. Epub 2011 Mar 26.
    Hahne H | Kuster B
    Online reference
  • 2010

  • Confident phosphorylation site localization using the Mascot Delta Score.
    Mol Cell Proteomics.; 2011 Feb;10(2):M110.003830. Epub 2010 Nov 6.
    Savitski MM | Lemeer S | Boesche M | Lang M | Mathieson T | Bantscheff M | Kuster B
    Online reference
  • Confident phosphorylation site localization using the Mascot Delta Score.
    Mol Cell Proteomics.; 2010 Nov 6. [Epub ahead of print]
    Savitski MM | Lemeer S | Boesche M | Lang M | Mathieson T | Bantscheff M | Kuster B
    Online reference
  • Proteomics: a pragmatic perspective.
    Nat Biotechnol.; 2010 Jul;28(7):695-709. Epub 2010 Jul 9.
    Mallick P | Kuster B
    Online reference